Osteomyelitis in the diabetic foot

X-ray · MRI

First and second year — the floor first, then every step

Radiographs are late; MRI decides. Osteomyelitis is low T1 marrow signal CONFLUENT with a medullary pattern, contiguous with an ulcer or sinus tract — oedema alone, or a neuropathic joint, is not osteomyelitis.

Orient first

  • Diabetic foot osteomyelitis spreads contiguously from an ulcer — the bone under the ulcer is the suspect bone.
  • Charcot neuroarthropathy affects the midfoot joints, is peri-articular and subchondral, and usually has no ulcer; osteomyelitis is at pressure points (toes, metatarsal heads, calcaneus) under an ulcer.
  • A radiograph cannot show marrow oedema; on MRI, T2/STIR oedema without T1 change is "osteitis" or reactive oedema, and confluent T1 marrow replacement is osteomyelitis.

Acquire the study

  • Three views of the foot; comparison with prior films.

The manoeuvre

  • Cortical destruction, periosteal reaction and loss of the cortical line under an ulcer — compare with the prior radiograph.
  • Soft-tissue gas and foreign bodies on two views.
  • Progression over 2 weeks on serial radiographs.

What confirms it

  • Confluent T1 marrow replacement contiguous with an ulcer or sinus tract.

What licenses you to exclude it

  • Normal T1 marrow signal makes osteomyelitis unlikely even with STIR oedema.

The classic misread

  • Calling a normal radiograph a negative study — it lags by 10–14 days.

See it on real cases

Direct links to Radiopaedia — the reference article and worked cases with their images. Each opens on Radiopaedia.

Key papers

Reviews and guidelines from RSNA, ESR and related journals. Each opens at its DOI.

  1. Use of MR imaging in diagnosing diabetes-related pedal osteomyelitis ↗Donovan A, Schweitzer ME · RadioGraphics 2010RSNA · PubMed
  2. T1-weighted MRI characteristics of pedal osteomyelitis ↗Collins MS, Schaar MM, Wenger DE, et al. · AJR 2005ARRS · PubMed
  3. Imaging of the Diabetic Foot ↗Garcia-Diez AI, Tomas Batlle X, Perissinotti A, et al. · Seminars in Musculoskeletal Radiology 2023 · PubMed
  4. The Charcot foot: a pictorial review ↗Rosskopf AB, Loupatatzis C, Pfirrmann CWA, et al. · Insights into Imaging 2019ESR · PubMed
  5. How to do and evaluate DWI and DCE-MRI sequences for diabetic foot assessment ↗Martín-Noguerol T, Díaz-Angulo C, Vilanova C, et al. · Skeletal Radiology 2024ISS · PubMed

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