Xanthogranulomatous pyelonephritis

CT

First and second year — the floor first, then every step

An enlarged, non-functioning kidney with a central staghorn stone and dilated calyces replaced by low-attenuation material (bear-paw sign), spreading into the perinephric space — the chronic infection that mimics tumour.

Orient first

  • Chronic obstruction (staghorn calculus) with infection replaces parenchyma by lipid-laden macrophages.
  • Diffuse form is typical; a focal form mimics renal cell carcinoma.
  • Extension into the psoas, bowel or skin (fistula) is common.

Acquire the study

  • CT with unenhanced and nephrographic phases; coronal reformats.

The manoeuvre

  • Unenhanced series: central staghorn calculus in a contracted pelvis.
  • Nephrographic phase: dilated calyces with low-attenuation contents and thin enhancing rims (bear-paw pattern).
  • Perinephric extension: fat stranding, collections, psoas abscess.
  • Fistula to bowel or skin.
  • Contralateral kidney function and stones.

What confirms it

  • Enlarged non-functioning kidney with staghorn stone and bear-paw calyceal replacement in a patient with chronic infection.

What licenses you to exclude it

  • A kidney without a stone or obstruction makes the diffuse form unlikely.

The classic misread

  • Calling focal XGP renal cell carcinoma — histology may be needed.

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